After purchasing, I profile immediately after getting them home but I've still got over 100 titles still unopened...some of them were purchased almost a year ago. So far I haven't run across any missing, defective or incorrect discs...knock on wood .

I generally open them when I watch them, though for reasons stated I need to get into the habit of opening them when I get them. I had one movie (Maverick) that had what I could only describe as a tar smear on the disc (the widescreen side of course) and was lucky I opened it and found it within the return period.

I have sinced opened up a bunch of ones I haven't watched yet, but still have a lot of titles that I have not yet opened.

the profile gets added to my collection as soon as possible though.

-Agrare

I always open them, take out the security device (my pet peeve, hate those damn things), and enter it in to my collection. When I bought Little Miss Sunshine when it just came out, there were two discs in there! So I now have a back-up.

I purchase mostly from a real store vs online because I hate to wait for a purchase to arrive. 

From the real store, if I'm picking up a used copy I make them open it right there in the store so I can check the condition of the disk.  If new, I open everything out in front of the store, tossing out security stickers and any inserts that are just advertisements. 

All the opened cases are then slipped back into the bag, taken home, and immediatly entered in Profiler.  Disks are removed from the cases and stored in the DJ boxes and the empty cases are added to the pile that I let grow until I've enough to fill another large plastic storage bin to add to those already under the house.